Yangjinhua is a flower of the white mandala Darura me L. Mainly produced in Jiangsu, Zhejiang, Fujian, Guangdong and other places. When the flowers are in full bloom from July to September, they are harvested, dried or dried at low temperature. For raw or ginger juice, wine.
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[Efficacy] Asthma and cough, anesthesia and analgesia, stop phlegm.
ã€application】
1. Asthma cough. This product is used for adult or elderly cough and innocence, but it is used by people who are ill-treated. It can be used as a powder or a cigarette to make a cigarette. It is also often used in combination with chronic asthmatic bronchitis and bronchial asthma.
2. Pain in the heart, rheumatism, pain, bruises. This product has good anesthesia and analgesic effects and can be widely used in a variety of pain diseases. It can be used alone or in combination with Chuancaowu and turmeric. Treatment of pain, bruises, in addition to decoction orally, can also be washed or applied.
3. Epilepsy, children are slow and stunned. This product has the function of relieving phlegm and stasis, and it can be used together with sputum, Tianma, and Tiannanxing to enhance the efficacy.
[Usage and Dosage] Oral, O. 2 ~ 0.6g, suitable for pills, powder; for cigarette smoking, the amount of no more than 1.5g a day. Appropriate amount for external use, decoction or external application.
[Note for use] This product is toxic and should be controlled. Exogenous and hot cough, glaucoma, high blood pressure, tachycardia are prohibited; pregnant women, infirm are used with caution.
1. Chemical composition: White mandala flower contains decane type alkaloids. Among them, it mainly includes scopolamine (astaxidine), saponin (asparagus), atropine.
2. Pharmacological effects: Scopolamine mainly inhibits certain parts of the cerebral cortex and subcortex, causing loss of consciousness and anesthesia. However, there are different degrees of excitatory effects on the medulla and spinal cord; there is a certain analgesic effect. It has a relaxing effect on bronchial and gastrointestinal smooth muscle. There is atropine-like vasospasm, which improves microcirculation and blood perfusion of tissues and organs and has anti-shock effect. There are dilated, regulating eye palsy and inhibiting glandular secretion. The golden alkaloids can significantly increase the activity of superoxide dismutase (SOD) in blood and cerebral cortex and reduce the content of malondialdehyde (MDA). When the alkaloid is administered at a small dose, the vagus nerve center is excited to slow down the heart rate; when the dose is large, the cardiac M-choline receptor is blocked, and the heart rate is accelerated. Higher concentrations of steroids have antiarrhythmic effects and non-specific calcium channel blockade.
3. Clinical research: Zhichuanling injection (mainly composed of Yangjinhua and ephedra), intramuscular injection of antibiotics to treat asthma in infants and young children, the total effective rate is 96.7%, significantly higher than the oral control group of aminophylline (Journal of Wenzhou Medical College, 1993, 4: 239); with Huaxianzi Capsule (Yangjinhua, Shimakozi, American Ginseng, Xianling spleen), morning and evening service, treatment of ankylosing spondylitis, the total effective rate of 92.7%, the effect is better than indomethacin (Guangxi Medical, 1994, 2: 156); Yangjinhua injection, intramuscular injection every night before bed, treatment of 5 cases of allergic subsepticemia, were cured. (New Chinese Medicine, 1988, 11:35); 102 cases of sports sickness vertigo were treated with acupuncture points containing Chinese medicinal alkaloids (halo vomiting), the total effective rate was 83.23%. It also has a certain alleviation effect on stun of Ménière's syndrome and vomiting caused by radiotherapy and chemotherapy (Journal of Beijing University of Traditional Chinese Medicine, 1993, 6:40);
4. Adverse reactions: excessive consumption caused by excessive poisoning, children are more common. Symptoms and signs of poisoning can be classified into two categories: one is parasympathetic dysfunction, including dry mouth, nausea and vomiting, skin flushing, heart rate, rapid breathing, dilated pupils, blurred vision, etc.; Systemic symptoms are mainly: gait instability, lethargy, confusion, paralysis, incontinence, arrogance and even convulsions, hyperreflexia, etc. Individual patients may have fever, elevated white blood cells, and increased neutrophils. In severe cases, death can occur due to paralysis of the respiratory center. Detoxification measures: Within 4 to 6 hours, the stomach is washed with water or a 1:5000 to 1:2000 potassium permanganate solution. For more than 4 hours, it should be diarrhea with magnesium sulfate, and intravenous infusion with glucose injection. Those without urine can be intravenously injected with 20% mannitol 250ml or furosemide 40-80mg. The antagonist may be pilocarpine or physostigmine, or the anticholinesterase drug neostigmine. In addition, symptomatic treatment and antibiotics should be used to prevent infection and insulation measures should be taken. Chinese medicine can be used to save 30g of licorice, 60g of mung bean, and fry soup; or use mung bean 120g, silver flower 60g, forsythia 30g, licorice 15g Jianshui. You can also use windproof, cassia twig soup.
[Others] The leaves and seeds of this product have analgesic effect, and scopolamine is the main component. The same genus hair mandala D. Innoxia Mill. , purple mandala D. Tatula L. Aumandala D. Stramonium L. Etc., all with the same product.
ã€Abstract of Ancient Books】
1. "Hunting Rock Materia Medica": "Treat cold and wet feet, face broken, sores, dried for the end, with a little stick to the affected area."
2. "Compendium of Materia Medica": "The wind and cold and wet athlete's foot, Jiantang wash; and the main epilepsy and rectal prolapse; combined with anesthesia."
3. "Materia Medica": "The pain of sores and ulcers, and the roar of the cold."
[Medicine] Xin, warm. poisonous. Return to the lungs, liver.
[modern research]