The only small animal on the market that can distinguish between subcutaneous fat and visceral fat
Hitachi-Aloka (Hitachi-Aloka) is a well-known name in the world of imaging. It has the reputation of “professional Aloka†in the field of ultrasonic imaging in the world. It is the pioneer of ultrasound medicine and the first to achieve 3D ultrasound. the company. Hitachi-Aloka has always been committed to creating superior leading image technology and continuously contributing to the society.
Latheta LCT-200 is a high-end live Micro-CT scanning system from Hitachi-Aloka. It is ideal for morphological observation of laboratory animals represented by mice and rats. It has nearly 200 laboratories worldwide. client. The LCT-200 provides the most advanced cadmium telluride detector for direct detection of X-ray intensity technology, providing customers with high-resolution, high-contrast, respiratory and heartbeat synchronous high-speed tomography high-quality imaging, and its powerful software database can provide 28 measurements. Indicators: including body fat percentage, subcutaneous fat content and body fat content, fatty liver analysis, brown fat analysis; bone salt density: total bone salt density, cortical bone salt density and spongy bone salt density; morphology: cortical bone thickness, Cortical bone and trabecular area ratio; minimum of mechanical properties and secondary motion of the polar area.
LCT-200 covers high-resolution imaging of living and ex vivo bones, cardiovascular research (skeletal nourishment, tissue vascularization, angiogenesis, perfusion studies, etc.), tumor models (tumor metastasis, tumor volume analysis, etc.), soft tissue enhanced visualization (organs, muscles, fat, etc.), diabetes and transgenic animal models.
1. Small animal CT measurement of fatty liver
Fatty liver is an excessive amount of fat in the liver, which is a common disease, and the incidence rate is 5% in the Chinese population. With the improvement of people's living standards and changes in dietary structure, the incidence of fatty liver has increased.
There are many factors that cause fatty liver, such as chronic alcoholism, nutritional deficiencies or overnutrition, hyperlipidemia, diabetes, endocrine disorders, etc., can cause fatty liver, especially related to elevated blood lipid levels. And as the age increases, the incidence increases, and the incidence of women after menopause also increases significantly.
Diagnosis of fatty liver, generally based on medical history, etiology, hepatomegaly, high blood lipids, B-ultrasound found in the liver dense microscopic waves, etc., confirmed by liver puncture for biopsy.
Although most patients with fatty liver have no symptoms, they are found in the physical examination, but the harm of fatty liver can not be ignored. It is reported that the incidence of fatty liver fibrosis is 25%, about 1.5-8% of patients can develop cirrhosis, alcoholic fatty liver can be sudden death.
The study of fatty liver is therefore imminent, but how to conduct effective fatty liver measurements has been plaguing our scientific research. The LCT200 measures the function of fatty liver to make this problem more satisfactorily resolved. Since the partial distribution of fat in the liver is very uniform, we can select a typical part of the liver, such as a part of the right lobe of the liver, using analytical tools, such as a circular selection tool, and then continuously selecting ten slices to form a cylinder. The liver volume of the liver can be calculated by calculating the fat percentage in the fatty liver, and the result is shown as a percentage of the fat content. In one experiment, the fat content of normal mice was 9.8%, while the fat content of obese mice reached 27%, which was a significant difference.
2. Small animal CT in the study of fat rate (Latheta LCT 200)
In diabetes or other metabolic disease studies, the percentage of fat (or fat percentage) is a very important indicator. How to accurately measure fat in the body has always been a problem for researchers. Early research may require the animals to be sacrificed and then stripped of fat for quantification, which may be a more accurate method in the early stages. But in fact, sometimes this method is not accurate. For example, some fats are difficult to distinguish and peel off, and it is impossible to completely separate the fat, so it is impossible to accurately quantify.
Some large scientific research equipment such as nuclear magnetic resonance and PET/CT can perform fat quantification, but these devices are often very expensive and cannot be tolerated by ordinary research units. Moreover, PET/CT is a radioactive instrument, so the general laboratory does not have the conditions and qualifications to install such instruments. If you go to a unit with these devices to do experiments, you will often face problems such as scheduling problems, management of radioactive reagents, portability of experimental animals, survivability of experimental animals, and normal operation of instruments and equipment.
The Latheta LCT-200 small animal CT solves the above problems well. Using a simple CT scan, using the patented technology developed by Hitachi-Aloka, the software accurately calculates the fat percentage of the experimental animals without killing the experimental animals. Conducive to long-term research in experimental animals.
2. Distinguish between subcutaneous fat and visceral fat
Latheta LCT-200's built-in software distinguishes between subcutaneous fat and visceral fat, and is therefore of great practical significance for researchers involved in energy metabolism, fat metabolism, diabetes research, and metabolic disease research.
At present, the ability to distinguish between subcutaneous fat and visceral fat is a unique feature of the Latheta LCT200, and no other product can do this. Moreover, the operation of this feature is not complicated, and anyone can perform analysis and operation with simple training.
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