Release date: 2017-07-25 When we talk about Silicon Valley, what are we talking about? Hewlett-Packard, Apple, Google, Facebook, Tesla, SpaceX's black technology, and small startups that suddenly appear in public view every few years. In fact, there is another mysterious genius. In the lesser-known non-profit research institutions in Silicon Valley, we use a series of research results to change our world in a low-key way... SRI International is one such institution. In the past, there were countless star projects that were born here and were acquired or split up by big companies to set up the company: the invention of Tide laundry liquid base materials, check magnetic security ink, mouse prototype, inkjet printer, CD and LCD display, and the world's first The realization of internet communication... Even Siri, the smart assistant in the Apple operating system, was originally an internal startup project of SRI International. It is no exaggeration to call this institution the Whampoa Military Academy in Silicon Valley... SRI International's research direction also includes medicine, they are studying how to diagnose and overcome cancer early! Previous studies in the medical community have found that some cancers are controlled by pairs of genes A and B, which are called "Synthetic Lethals." Assuming that the A gene lesion fails, B will increase the expression to compensate for the loss of A, and maintain the cancer cells to continue to proliferate, and vice versa. If A and B can be simultaneously diseased, the cancer cells they control will die and the cancer will stop spreading. As a result, the medical community began to use this theory to develop medicine and treatment programs, but the results were not ideal. The threshold is that you want to accurately confirm this pair of genetic relationships, just like finding a needle in a haystack. SRI International's bioinformatics team, led by Stanford University researcher Subarna Sinha, led a major breakthrough in medical and computer science! The team developed a new computer algorithm called Mining Synthetic Lethals (MiSL). Through the new algorithm, the team screened 12 different types of cancer, more than 3,100 cancer-related genetic lesions, and hundreds of millions of genes, and accurately selected 89 pairs of synthetic lethal genes. Even more gratifying is that 17 of these have been discovered before, put into clinical applications or drug development - proving the effectiveness of the MiSL algorithm! At the SIS2017 of the Silicon Valley Technology Summit held last week by PingWest, Xin explained this new discovery to hundreds of professionals. According to her, MiSL can be used not only to discover potential synthetic lethal genes, but also to introduce new data sources for reverse verification and to find genes that cause resistance to existing cancer drugs, thus expanding new research... Xin pointed out that the birth of the MiSL algorithm is a milestone in the war against cancer. Through MiSL, in the future we may usher in more targeted anti-cancer therapies for individual patients, even defeating cancer completely one day... Source: PingWest
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