one. Foreword
The production of Chinese herbal medicine pills has always been in the form of manual or water-pill re-plasticization. Since the emergence of the mechanism pills in the 1970s, the mechanism pills have been rapidly promoted with uniform size and large yield. To this end, with the research process of the process and process of the pill, the equipment and equipment for the development and manufacturing of the pill. There are institutions that specialize in studying the pharmacological properties of the pills and so on. The traditional Chinese medicine mechanism pill has the ability to be quantitatively weighed, and is in line with the internationally accepted mode of administration. It is easy to pack, easy to store, and easy to carry. Therefore, the development prospect is very broad.
two. Pellet process
The process requirements for the manufacture of pills in the mechanism are: to ensure that the production plant, environment, production equipment, production materials, hygiene, etc. meet the requirements of good Manufacturing Practices (GMP).
The process route of the Chinese herbal medicine mechanism pill is: pulverization and sieving of the drug → mixing of ingredients → mixing → refining → pilling → screening.
three. Equipment needed for pelleting
In order to cooperate with the above process, the equipment required for the production mechanism pill is: washing machine, slicer, pulverizer, various sieving machines, various mixers, refining machines, pelleting machines, automatic dusting machines, pills Granule screening machine, pill polishing machine, etc. Here, we focus on the process and equipment required for mixing, refining, and pelletizing wet powdered drugs. (The mixing of dry powder materials mainly uses two-dimensional mixers, three-dimensional motion mixers, etc., which will not be described here)
1. CHJ-200 groove mixer:
This type of equipment can be widely used in the pharmaceutical, food, chemical and other industries. In the pill
Medium, mainly used to powder powders with various ingredients, concentrated cream, refined honey, water, etc.
Mix and stir evenly in the tank, and the mixing process does not allow the melting, volatilization or deterioration of the material.
The feeding of the equipment is still carried out by manual weighing and then pouring, and the discharging is carried out by the body automatically tilting.
The equipment has a capacity of 200 liters, 400 liters, and the like. It is commonly used with 200 liters of zui.
2. GHL-30 refining machine:
This type of equipment can be widely used in the pharmaceutical, food, chemical and other industries. Pilling process
The main material is used to mix the material of the trough mixer into the equipment, and the material to be processed is made into uniform tissue, soft and hard, and water content by the screw extrusion of the pressing plate and the screw propeller. The same material. These materials can be discharged in the form of round strips, plates or shaped strips.
The equipment has good refining production for difficult-to-process materials such as high-hardness materials (concentrated paste and dry powder, cold and hard after hot mixing) and high-viscosity materials (refined honey and dry powder). It is an indispensable process before pelleting.
The output of the equipment can reach 300-500 kg / hour.
3. YUJ-16, 17, 18, 22 series pill making machine:
The pelleting machine is further divided into large pills having a weight of more than 1 gram; (a diameter between 10 and 30 mm) of pellets having a weight of less than 1 gram. Including water pills, water pill, concentrated pills, honey pills, Tibetan pills. (The diameter is between ～2~10mm) The working principle of the pelletizing machine is to mix the powder with the binder (water, honey, extract or paste and stir evenly. After refining, the medicine is made into a round strip. Then cut into granules and then smash into pellets at high speed.
The pilling machine is divided into two types: vertical and vertical. In the practical application of the pharmaceutical factory, the horizontal strip has considerable advantages in the manufacture of pellets, so it is widely used. Vertical pelleting machines have been eliminated. In the mechanism of the pill, the pelleting machine is one of the important equipments of Zui, and it is very important for the rapid production of uniform spherical pellets. To this end, each pharmaceutical machine manufacturer has invested considerable effort in research and development and improvement.
Tianshui Huayuan Pharmaceutical Equipment Technology Co., Ltd. has stepped into the leading enterprises in the country in the production of pelleting machines. Pilling machines already have 5 series and 14 varieties. Both large and small pills can be made. There are only 3 national patents on the pill machine. Its market share has reached 60%, and its development prospects are very broad. Take the typical YUJ-17BZ automatic speed control Chinese medicine pill making machine as an example: the machine adopts high-tech such as PLC programmable controller and encoder. The dragging part is controlled by an imported frequency converter, and the human-machine interface of the touch screen operation is simple to operate. Well received by the majority of pharmaceutical companies.
The refining and pelletizing machine YUJ-17BL combines the functions of two refining and pelletizing equipments in one country in the original, and the machine has also obtained national patents. There is also a bench-top pelletizer YUJ-10A, which is used exclusively in laboratories or small research institutes for small, multi-batch pelleting. The output of various types of pelletizers can be selected between 5 and 180 kg/hr. There is also an automatic shot peening machine CWJ-28, which is mainly used for rounding the roundness of the pellets and making the surface smooth. This model is equipped with two curved rafts, which are matched with two stainless steel rollers, and are especially suitable for rounding of pellets with diameters between Ñ„6 and Ñ„10.
In the process of working in the pelleting machine, according to the medicinal properties, in order to prevent the adhesion of the pills, some need to spray 95% of the medical alcohol on the pills, and some need to sprinkle the original powder or medical starch on the surface of the pills after the pills are formed.
4, SFJ-300 automatic dusting machine:
SFJ-300 automatic dusting machine is a new product newly developed by our company and is the first domestic production. The aircraft has also obtained national patents. Its main function is to match all kinds of pill making machines, and to process the prepared pill powder, so that a uniform layer of powder is adhered to the surface of the pill and smoothly enters the next process.
The machine is the first in China, not only has a delicate design, beautiful appearance, reasonable structure, but also completely replaces the traditional manual dusting process. The pill from the pill mechanism passes through the feed hole end and enters the duster drum. The powder of the hopper is uniformly dusted into the drum by the electric round brush, and adheres to the surface of the ball. The ball is driven by the roller. And rolling at a constant speed, and then moving through the spiral to move to the exit, thereby achieving the function of uniformly adhering the powder on the surface of the pellet.
This machine is the first choice for the upgrading and process improvement of the pill production equipment in the pharmaceutical and food processing industries. The output of the duster can be selected between 5 and 280 kg of pills per hour.
5, TYJ-300 automatic oiling machine
TYJ-300 automatic oiling machine is a new product newly developed by our company and is the first domestic production. Its main function is to match the big honey pill pelletizing machine, and the prepared pellets are coated with edible oil on the surface, and smoothly enter the next process.
6, pellet screening machine
The main purpose of the pellet screening machine is to screen and distinguish the size of the pills. There are two kinds of screening: one is that the wet pill is screened after micro placement; the other is the screening of dry pill.
For the screening of wet pellets, there are two types of vibrating separation screens and pelletized drum screens, and the precision of the sieve diameter can reach 0.25 mm. Huayuan Company has SWZ-550 vibrating separation screen; SWG-500 and SWG-600 type pelletizing screens are widely used.
For the screening of dry pellets, there are two types of XF-9 four-stage separator and SWL-5 spiral separator. The XF-9 four-stage separator is an intermittent swing screen. With time relay control, only the appropriate screen can be replaced during use to achieve the desired screening effect.
SWL-5 spiral pilling machine. It is a spiral tower mechanism and is a device without mechanical power. When working, the material is sent to the high inlet, and the pill is naturally rolled down by its own weight and spiral track. The pill is screened by the difference of the speed of the good and bad pill, and the irregular shaped pill and double pill are separated. This machine is especially suitable for the screening of dry pills.
7, automatic polishing machine
After the mechanism pill is made, after screening, the surface of the pill should be polished. The purpose is to round and polish the pills. The polishing equipment used is: BYJ series è¸è type coating machine (sugar machine), continuous conveying and polishing machine, continuous automatic drum polishing machine, etc.
1BYJ series coating machine, mainly used in the pharmaceutical and food industries. In the pharmaceutical factory, it is used for glazing, coating, and granulation of water pills. BYJ series coating machine feed is manual, the discharge mode is automatic, can not be operated continuously, according to the volume of the pot body in batches. The machine is equipped with internal and external heating and preheating air.
2PGJ-1000 continuous conveying and polishing machine, which is mainly used for lighting and coating of pharmaceuticals in pharmaceutical factories. It is a continuous operation and automatic feeding and discharging. The machine is equipped with a turning plate and an infeed and discharge conveyor (slot) for high production efficiency. The aircraft has already applied for national patents.
3PGZ-600 continuous automatic drum polishing machine, which is also used for lighting and coating of pharmaceuticals in pharmaceutical factories. It is a continuous operation and automatic feeding and discharging. The machine is equipped with an automatic dusting machine at the entrance of the machine. There is a turning plate in the drum and an automatic pouring hopper at the joint, which has high production efficiency. The aircraft has also applied for national patents.
In addition, there are equipment for serving the pill production line: such as Chinese medicine microwave extraction tank, concentration tank, Chinese medicine microwave countercurrent extractor, microwave vacuum dryer, tunnel microwave drying and sterilizing machine, box vacuum microwave dryer, BG series with holes Non-porous coating machine, packaging line equipment (automatic bottle unscrambler, rotary granulator, orbital photoelectric counting machine, cup type granulator, automatic paper plucking machine, automatic linear capping machine, electromagnetic induction aluminum foil Sealing machine, vertical self-adhesive labeling machine, etc.; intermediary equipment for the production of pill production line: such as flat conveyor, vertical vibration hoist, heating hoist, pill blasting machine, swinging granulator, etc. Huayuan Company has production.
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