The American Origen Treatment Company announced today that they have used eggs for the first time to produce fully functional human monoclonal antibodies. This antibody is expressed only in chicken fallopian tubes and produces 1 to 3 milligrams of antibody per egg, which is precipitated in the protein and compared to therapeutic antibodies produced by traditional cell culture methods. Antibodies produced using this novel method There is a 10- to 100-fold greater ability to kill cancer cells than the traditional method of producing antibodies. To raise chickens that produce antibodies, the researchers first inserted the genes encoded by the antibodies into chicken embryonic stem cells, which were then introduced into chicken embryos. In the developmental stage, embryonic stem cells play an important role in growing chickens. The eggs that are produced in the mixed breeder chickens contain milligrams of antibodies and these antibodies are separated from the proteins of the protein, resulting in purified monoclonal antibodies. "The antibodies produced by this method have very similar physical and biological properties to those produced using cell culture methods. In addition, antibodies produced in chicken have no sugar residue." --- Fucose, therefore, has the power to enhance the killing of cancer cells.At present, the U.S. government has approved more than 25 types of monoclonal antibodies for clinical treatment. We anticipate that there will be more demand for anti-cancer monoclonal antibodies. The current cell culture method is not only far from satisfying the demand, but is also not conducive to reducing costs. The adoption of chicken-based production technology will enable the industrialization of large-scale production of therapeutic antibodies." The president of the company, Robert Kay, said: "We believe that Producing monoclonal antibodies from chickens is the most effective method compared to the production of monoclonal antibody systems in phytosystems or other transgenic animals.The time required to produce antibodies from eggs can be as short as 8 months, and goats or cows can be used to produce singles. Identification of cloned antibodies takes 18 months to 3 years, and eggs are sterile and stable. A good starting material was provided.The study was funded by the U.S. Institute of Health, and the research results were published in the September issue of Nature Biotechnology and published in the September issue of Natural Medicine. New Technology Review US genetic engineering experts announced on the 29th that scientists have jointly used stem cell technology and transgenic technology to produce fully functional human monoclonal antibodies from eggs for the first time.The researchers said that this breakthrough is expected to significantly improve monoclonal antibodies. Drug production efficiency and cost reduction The above-mentioned research results jointly obtained by scientists from Orijin Pharmaceuticals, Texas Agricultural University, and UCLA have been published in a new issue of the journal Nature Biotechnology. They first implanted genes encoding human monoclonal antibodies into chicken embryonic stem cells, and also implanted a gene encoding a monoclonal anti-aggregation site so that monoclonal antibodies can only be present in egg proteins, and then the transgenic embryonic stem cells Implantation of chicken embryos so that hatched chickens can be produced after 8 months An egg containing human monoclonal antibodies was produced.The researchers said that the genes encoding human monoclonal antibodies are expressed in the fallopian tubes of chickens, and the antibodies produced are only found in egg proteins. Each egg contains antibodies of 1 to 3 milligrams. Easy to purify. The characteristics of monoclonal antibodies carried by eggs are almost the same as those produced by traditional methods, but the ability to kill cells is 10 to 100 times higher. Monoclonal antibodies are synthesized by B lymphocytes and only work for one antigen. Monoclonal antibody drugs have the advantages of precise and controllable drug efficacy and small side effects, and can be applied to the treatment of cancer, arthritis, and immune system diseases, and are a hot spot in the pharmaceutical industry. Monoclonal antibody drugs are known as the most promising anticancer drugs. Drugs, the United States has so far approved the listing of 25 monoclonal antibody anti-cancer drugs, there are more drugs in the approval phase, so the pharmaceutical industry has a huge demand for monoclonal antibodies. American genetic engineering experts point out that so far, humans Monoclonal antibodies are also produced in culture media, which have low yields and high costs. Production of monoclonal antibodies from eggs produces high yields. Short-term, no sugar egg proteins, monoclonal antibodies can be guaranteed not easily be contaminated, you can also follow the existing production equipment vaccines with eggs, is expected to significantly reduce the manufacturing costs of monoclonal antibodies. According to sciam.com, reported on August 29, in the past 50 years, eggs have been closely linked with the production of influenza vaccine, which plays an extremely important role in the manufacture of influenza vaccine. Now scientists have a new interest in the common foods on this breakfast table. Scientists have created eggs containing human antibodies by transplanting the genes controlled by human control antibodies into egg stem cells. The antibody molecules in these eggs can completely mimic human own antibodies to deal with certain specific invading viruses. The cells in the human immune system that can produce antibody molecules are called B lymphocytes by scientists. They can produce different kinds of antibodies. Each type of B lymphocyte produces an antibody. Scientists think that if they can reproduce a certain type of B lymphocyte, then it can create a large number of single antibody molecules to fight the invasion of a certain invading virus. Scientist Robert J. Etches has been working on research in the field of human antibodies. He said: "The massive replication of antibodies has shown tremendous power in the human medical field. It has been widely adopted by health care workers in clinical medicine. But now The method of mass-producing human antibodies is still not perfect, and its production is very low. Scientists hope to find newer methods to produce more and cheaper antibodies to perfect the current antibody production system." To achieve this goal, Etches and his colleagues thought of eggs - a common food in everyday life. They hope to make cheap and attractive human antibody molecules through hens and eggs. First, they took out the human B-lymphocytes that contained certain antibody information and the genes that controlled the behavior of the antibodies, and then implanted them into embryonic stem cells of chicks inside eggs. Then these eggs slowly matured. When the hens finally produce these eggs, the eggs contain a large number of antibody molecules that people want. Scientists' experimental research reports have been published in the Journal of Natural Biotechnology. According to the report, antibody molecules made from chicken eggs are extremely resistant to invaders. They are ten to one hundred times more resistant than the antibody molecules produced by ordinary methods. The current general method for producing antibody molecules usually takes eight months, and the time required for the method of manufacturing human antibody molecules from eggs is very short, and this method leaves the antibodies away from the pollution of the surrounding environment due to the natural spacer eggs. Currently, scientists are perfecting this method and will one day extend this method of producing human antibody molecules from eggs to all parts of the world.
Nitrate Products
Sodium Nitrate,Potassium Nitrate,Strong Oxidizer
Xuzhou First Chemical Co., Ltd , http://www.chfertilizer.com