Swine fever virus infection

The swine fever is also called rotten bowel and pig cholera. It is an acute, feverish, contact infectious disease caused by swine fever virus infection. Acute disease will be sepsis changes, the slower course of the disease, characterized by fibrointestinal enterocolitis, in the vicinity of the ileocecal soft layered ulcers, so the valley is called rotten intestinal fistula. The pathogenic bacteria can be pathogenic throughout the year without obvious seasonality. It can be infected regardless of pig species, age and sex. The incidence of pathogenic bacteria and mortality is extremely high, and the infection is rapid.

[pathogen] is swine fever virus, round or portal-shaped. Exist in the pig's blood, secretions and excrement (eyelids, feces, urine, etc.). Contaminated feed, drinking water, and utensils that are contaminated with secretions can transmit this disease. The virus is very resistant to the outside world. If the virus is present in the urine without fermentation, it is very difficult to lose its virulence and it can become a source of infection. In addition, poisonous pigs, dogs, poultry, flies, and transportation vehicles can also transmit the disease. Its route of infection is the digestive tract, respiratory tract, skin wounds, and conjunctiva of the eye; according to recent studies, it is also possible to pass vertical infection of the placenta, which brings certain difficulties to the disease.

Chinese veterinarians believe that. Due to poor husbandry and management, sudden changes in the climate, weakening of the ability of pigs to defend outside the body, and the incidence of epidemic outbreaks invading the body.

The main symptoms are different in incubation period, and are determined by the amount of virus entering the pig body, the size of the virulence, the strength of the pig's resistance and related factors, with an average of 4-10 days. Clinically divided into the most acute, acute and chronic swine fever.

The most acute form of the disease is acute and often falls to death without symptoms.

The initial temperature of acute type disease rises to about 41°C, and persists; the pig suffers from constipation first, and the black color is similar to that of abacus beads. The "lard"-like mucus is attached to it, and some diarrhea later, and the filth, odor, and faeces are pulled. Conjunctiva red, red and swollen, tears, eyelid adhesions; boar swollen, yellow fouling inside the accumulation of urine, hand squeeze a white odor urine outflow; boar pig common molars, drowsiness, turning, shaking his head or fell to the four limbs Twisted, eyeballs and other neurological symptoms: the disease to the middle and late, suffering from pigs inside the limbs, lower abdomen, ears and vulva and other hair pressure does not fade; some dry cough, dry breathing, breathing difficulties, showed chest breathing. It usually dies in 1-2 weeks.

Chronic disease course longer than 1 month, the main symptom is very irregular, body temperature is high and low, constipation and diarrhea alternately occur, but the following scrofula mainly; sick pig weight loss, anemia, bow and abdomen, head and tail drooping, cough Some ears or tail tip appear dry, hind limbs are weak, and walking is shaking. Most of the sick pigs die, and survivors are also difficult to fatten and become stiff.

In recent years, an atypical swine fever has also emerged in various parts of the country, which is caused by a naturally variable low-virulence virus infection. The virulence of the piglets is strong, and sometimes there are some clinical symptoms. The general condition is mild, and even the typical symptoms and anatomical changes do not appear. However, viral serological reactions share common antigenicity. Both morbidity and mortality are low and are generally referred to as mild swine fever.

Anatomy can be seen: 1 whole body lymph node swelling, especially mesenteric lymph, the edge of the cut surface dark red, gray central, red and white, like a marble pattern; 2 spleen edge is often seen from the miliary black beans to the size of the black red protrusion Bleeding, commonly referred to as "infarction"; 3 the large intestine, especially the ileocecal circumcision often round button-shaped middle protrusion round button ulceration, so the masses call it "rotten gut"; 4 kidney color is pale, the surface is often There are scattered or dense needles to debate the bleeding point; 5 Bleeding in the bladder and throat.

【Prevention and Treatment】 At present, there is no specific drug treatment for the disease, and comprehensive prevention measures such as immunization should be used to control the occurrence of this disease. Some take some symptomatic therapies and Chinese herbal medicine treatment to obtain a certain effect.

Routine vaccination is an effective measure to prevent swine fever. Use swine quails to attenuate attenuated virus vaccine (or live cell culture vaccine) to subcutaneously or intramuscularly inject 1-2 ML into the litter (50-60 days of age). The swine fever vaccine; The sow is injected once a year in the empty period. The boar is injected with 1 injection every year to achieve pre-effects. In addition, self-cultivation and self-cultivation are adopted, and the pigs are bred and no pigs are purchased. Management, pick up good health, regular disinfection is also an important measure to prevent the disease.

When the swine fever is infected, the following comprehensive treatment methods can be used to obtain a certain curative effect for reference.

1. If there is a group morbidity, an emergency inoculation method may be used. That is, if the body temperature is normal and no symptoms are present, swine fever vaccine (2-4 piglets) can be used to immunize once. The high-dose swine fever can be used for sick pigs with symptomatic temperature. The vaccine (10-30 doses) was administered intramuscularly, and its dose was adjusted according to the condition and weight of the patient. It was appropriate to use 0.5 part per kilogram of body weight. The severe cases were appropriately decremented. If necessary, repeated injections were repeated on the 3rd day. At the same time with the use of 654-2, anti-bacterial anti-inflammatory drugs, its efficacy is better.

2. The combination of Chinese and Western medicine treatment can use one of the following methods:

(1) Western medicine: erythromycin 600,000 units, with injection water 10ML, mixed and dissolved with 5%-10% glucose injection 150ML, 1 intravenous injection (40KG or more pigs), 2 times a day. Chinese medicine: Scrophulariaceae 14G Forsythia 13G Campanulaceae 16G Clam shell 14G Nepeta 7G Plantago 16G Ophiopogon 16 Winter Land 7G Anemarrhena 30G Gypsum 30G Mint 7G Silver 25G Dandelion 25G Licorice 10G Total fine, white rice Impulse irrigation, one dose per day, divided into two doses. This side has a certain effect on mild swine fever.

(2) Gypsum 50G Glauber's salt 30G Coptis 15G Astragalus 15G Forsythia 20G Licorice 10G. Ginseng fine gypsum research and mixing Glauber's salt, other medicine decoction 2 times, to the residue, while hot add gypsum, ground fine mix with Glauber's salt, other medicine decoction 2 times, to the residue, while hot add gypsum, Glauber's salt, wait for cold gavage. For pigs above 50KG, the dose of 20-50 pigs should be halved and the dose of 20KG should be 1/3 of the original dose. Increased appetite. After the manure is improved, the drug must not be discontinued and the drug must be continued for one course of treatment. The dose can be reduced by 1/2-1/3. If the manure is normal, it can go to rhubarb and thenardite. For chronically ill and frail pigs, they should also be supplemented with a strong heart, rehydration and antibiotic treatment. This method has a certain effect on mild swine fever.

(3) Western medicine: take erythromycin 250,000-75 million units, 25% glucose injection 20-80ML, mixed, intravenous injection of ear veins, while taking chloramphenicol 0.5-1.25G and 30% metabolite 10-20ML Intramuscular injection, once daily. Ferret: Take one ear of the dorsal side without a blood vessel in the middle and lower, and use a wide needle to pierce the subcutaneous sac under the skin and cover the needle eye. Medicinal: Radix Isatidis 30G Gypsum 100G Rehmannia 30G Campanulaceae 20G Coptis 15G Astragalus 20G Scrophulariaceae 20G Forsythia 30G Anemarrhena 30G Danpi 20G Erhua 20G Sapphire 20G Peach 20G Radix Astragalus 15G Rhubarb 2 and juice for warm-watered dung. Diluted Rhubarb, Glauber's salt, Thirst Worst add pollen, Ophiopogon 20G each.

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