Model NO.: YJ-Pharm2956
Trademark: YJ-Pharm
Transport Package: Cartoon
Specification: 1kg/foil bag
Origin: Shanghai
HS Code: 3201
Model NO.: YJ-Pharm2956
Trademark: YJ-Pharm
Transport Package: Cartoon
Specification: 1kg/foil bag
Origin: Shanghai
HS Code: 3201
 Quick Detail for MK-1775
Â
| Product Name |
MK-1775 |
| CAS |
955365-80-7 |
| MF |
C27H32N8O2 |
| MW |
500.59538 |
| Appearance |
yellow powder |
| Package |
50G/foil bag |
| Standard |
enterprise standard |
| Assay |
99% |
| Grade |
medical grade |
MK-1775 is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDK1, CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. MK-1775 is a type of biological therapy. It is a cancer growth blocker. It stops signals that cancer cells use to divide and grow. MK-1775 has been used in trials studying the treatment of LYMPHOMA, Neoplasms, Ovarian Cancer, Tongue Carcinoma, and Adult Glioblastoma, among others.
MK-1775Â Applicaiton
MK-1775 inhibits Wee1 kinase in an ATP-competitive manner. Compared to Wee1, MK-1775 displays 2- to 3-fold less potency against Yes with IC50 of 14 nM, 10-fold less potency against seven other kinases with >80% inhibition at 1 μM, and >100-fold selectivity over human Myt 1, another kinase that inhibits cyclin-dependent kinase 1 (CDC2) by phosphorylation at an alternative site (Thr14). By abrogating the DNA damage checkpoint via blockade of Wee1 activity in WiDr cells bearing mutated p53, MK-1775 treatment inhibits the basal phosphorylation of CDC2 at Tyr15 (CDC2Y15) with EC50 of 49 nM, and suppresses gemcitabine-, carboplatin- or cisplatin-induced phosphorylation of CDC2 and cell cycle arrest in a dose-dependent manner, with EC50 of 82 nM and 81 nM, 180 nM and 163 nM, as well as 159 nM and 160 nM, respectively. MK-1775 treatment alone at 30-100 nM has no significant antiproliferative effect in WiDr and H1299 cells, whereas MK-1775 at 300 nM, sufficient to inhibit Wee1 by >80%, displays moderate but significant antiproliferative effects by 34.1% in WiDr cells and 28.4% in H1299 cells.
We have following SARMS series
Â
| No |
Name |
CAS No |
| 1 |
LGD-4033 |
1165910-22-4 |
| 2 |
MK-2866 |
1202044-20-9 |
| 3 |
MK-677 |
1132656-73-5 |
| 4 |
GW-501516 |
317318-70-0 |
| 5 |
AICARÂ |
2627-69-2 |
| 6 |
SR9009 |
1379686-30-2 |
| 7 |
RAD140 |
1182367-47-0 |
| 8 |
Andarine(S4) |
401900-40-1 |
Our Advantage
| Best Quality |
Professional leading manufacturers in China.Strict
quality control before products are allowed to sell. |
| Competitive Price |
Factory direct sales.Best prices you're sure to be
satisfied. |
| Safe Packing |
Professional packing department which have more
than 16 years experience in disguising packages |
| Fast Delivery |
Plenty in stock,delivery within 24 hours after the
payment.Fast and secure delivery by DHL, TNT,
FedEx, HKEMS, UPS, etc. |
| Payment |
T/T,Western Union,Money Gram,Bitcoin. |
| Service |
Photos of parcel and tracking number offered
timely;24/7 online helpful service |
| Discount |
Specials are possible when client's order is big
enough, including the discount policy |
Â
 Quick Detail for MK-1775
Â
| Product Name |
MK-1775 |
| CAS |
955365-80-7 |
| MF |
C27H32N8O2 |
| MW |
500.59538 |
| Appearance |
yellow powder |
| Package |
50G/foil bag |
| Standard |
enterprise standard |
| Assay |
99% |
| Grade |
medical grade |
MK-1775 is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDK1, CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. MK-1775 is a type of biological therapy. It is a cancer growth blocker. It stops signals that cancer cells use to divide and grow. MK-1775 has been used in trials studying the treatment of LYMPHOMA, Neoplasms, Ovarian Cancer, Tongue Carcinoma, and Adult Glioblastoma, among others.
MK-1775Â Applicaiton
MK-1775 inhibits Wee1 kinase in an ATP-competitive manner. Compared to Wee1, MK-1775 displays 2- to 3-fold less potency against Yes with IC50 of 14 nM, 10-fold less potency against seven other kinases with >80% inhibition at 1 μM, and >100-fold selectivity over human Myt 1, another kinase that inhibits cyclin-dependent kinase 1 (CDC2) by phosphorylation at an alternative site (Thr14). By abrogating the DNA damage checkpoint via blockade of Wee1 activity in WiDr cells bearing mutated p53, MK-1775 treatment inhibits the basal phosphorylation of CDC2 at Tyr15 (CDC2Y15) with EC50 of 49 nM, and suppresses gemcitabine-, carboplatin- or cisplatin-induced phosphorylation of CDC2 and cell cycle arrest in a dose-dependent manner, with EC50 of 82 nM and 81 nM, 180 nM and 163 nM, as well as 159 nM and 160 nM, respectively. MK-1775 treatment alone at 30-100 nM has no significant antiproliferative effect in WiDr and H1299 cells, whereas MK-1775 at 300 nM, sufficient to inhibit Wee1 by >80%, displays moderate but significant antiproliferative effects by 34.1% in WiDr cells and 28.4% in H1299 cells.
We have following SARMS series
Â
| No |
Name |
CAS No |
| 1 |
LGD-4033 |
1165910-22-4 |
| 2 |
MK-2866 |
1202044-20-9 |
| 3 |
MK-677 |
1132656-73-5 |
| 4 |
GW-501516 |
317318-70-0 |
| 5 |
AICARÂ |
2627-69-2 |
| 6 |
SR9009 |
1379686-30-2 |
| 7 |
RAD140 |
1182367-47-0 |
| 8 |
Andarine(S4) |
401900-40-1 |
Our Advantage
| Best Quality |
Professional leading manufacturers in China.Strict
quality control before products are allowed to sell. |
| Competitive Price |
Factory direct sales.Best prices you're sure to be
satisfied. |
| Safe Packing |
Professional packing department which have more
than 16 years experience in disguising packages |
| Fast Delivery |
Plenty in stock,delivery within 24 hours after the
payment.Fast and secure delivery by DHL, TNT,
FedEx, HKEMS, UPS, etc. |
| Payment |
T/T,Western Union,Money Gram,Bitcoin. |
| Service |
Photos of parcel and tracking number offered
timely;24/7 online helpful service |
| Discount |
Specials are possible when client's order is big
enough, including the discount policy |
Â