Ionic composition and regulation of rat corneal wound current This 50m distance measuring meter is made of two parts: the laser distance outside unit and the sole part laser measure module. Great distance range is from 3cm to 50 meters with ±1.5mm high accuracy. Digital distance measuring device is quick and reliable measure with one hand pushing the button. It is designed for hand helding, very convenient to put in your jacket pocket or trouser pocket. 50M Laser Distance Measurer,Mini Laser Measurer, Laser Measure 50M,50M Laser Distance Meter Chengdu JRT Meter Technology Co., Ltd , https://www.cdlaserdistancesensor.com
The electric field and current inside the wound is a strong signal that guides the cell to migrate into the healing wound. The electric field stimulates the distribution, migration and differentiation of many cells, such as corneal epithelial cells, nerve cells, fibroblasts, and skin epidermal cells, which are electrotropic or electrotropic. The electric field and current appearing on human skin wounds have been detected many years ago, and new technologies can now more accurately measure changes in current, such as non-invasive micro-measurement techniques, bioelectric imagers, and the like.
In 2011, researchers at the University of California at Davis used non-invasive micro-test techniques to determine the kinetics of individual ion flux changes over time in rat corneal wounds, as well as the expression levels of Cl-channels before and after injury. The Ca2+ outflow increased after the injury, but the initial outflow of the K+ flow was large and then rapidly decreased. Surprisingly, Na+ in the wound showed an influx, as well as a continuous Cl-influx, similar to the previously measured wound current. Pharmacological experiments have found that the drug stimulates ion transport and significantly increases the flow rates of Cl-, Na+ and K+. Damage to the cornea caused significant changes in the distribution and expression of Cl-channel CLC2.
This study demonstrates that outward currents appear on corneal wounds, mainly caused by Cl-influx, and some Ca2+ and K+ outflows. The Ca2+ and Cl- flow rates are primarily activation regulation, but the K+ flow rate is primarily caused by leakage. Electrical signals are an activation response that can provide new ways to regulate wound healing, such as changing ion transport through eye drops to help challenge non-healing corneal ulcers. Therefore, we can develop eye drops suitable for the treatment of eye diseases.
Key words: current; ion current; wound
Quote: Vieira AC, et al. PLoS ONE, 2011, 6: e17411.
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Note: The contribution of the ion current in the wound current model and the actual contribution rate. Ca2+, Cl-, Na+, and K+ are involved in the formation of current.
Ionic Components of Electric Current at Rat Corneal Wounds