China's new biomedical polymer materials research has made important progress

Release date: 2008-04-24

China's new biomedical polymer materials research has made important progress
It was learned from the Changchun Institute of Applied Chemistry of the Chinese Academy of Sciences that researchers from the Institute of Chen Xuesi and Jing Yubin led the researchers of the Biological Research Group to prepare different kinds of biomedical polymer materials after nearly seven years of unremitting efforts and continuous exploration. The basic performance, functionalization, material preparation, biological evaluation and clinical application have been studied, and a series of breakthroughs have been made. The results have reached the international advanced level, and some of them are internationally leading research results, and recently won 2007. The first prize of Jilin Province Science and Technology Progress Award.
As materials for diagnosis, treatment and organ regeneration, biomedical polymer materials occupy a very important position in the fields of biotechnology, life sciences and medicine, and different fields of biomedicine have different biomedical materials. Claim. The institute's researchers aimed at this important direction of domestic and international attention. Under the support of the National Natural Science Foundation, the Ministry of Science and Technology, and the Science and Technology Department of Jilin Province, they undertook the research and application of new biomedical polymer materials in 2000. "project.
Based on the structural design and preparation of biomedical polymer materials, the Schiff base alkyl/alkoxy aluminum complex with a stereoselectivity of over 90% was synthesized for the first time to obtain polylactic acid (PLA) with a melting point of up to 201 °C. Materials; creatively using POM and micro-infrared spectroscopy to study the formation process of bicrystalline polyethylene glycol-poly-e-caprolactone (PEO-PCL) block copolymer concentric spherulites, and established a high crystallinity The basic research method of molecular crystallization behavior explains the influencing factors of various crystallization behaviors. For the first time, the highly selective stereoblock polylactic acid is used as the material, and the protein drug insulin is stereo-composited, and the three-dimensional composite action is combined. High-drug-loaded polylactic acid-protein complex; creatively proposed "emulsion electrospinning technology" to achieve simultaneous loading and controlled release of two drugs with different solubility, so that the combination and matching of drugs and carrier polymers No longer limited by the “common solvent”, the preclinical experiments of various drug sustained release agents were completed; a new method was established for the first time to implement HA/PLGA composites. Graft modification, the tensile strength and toughness of the composites are greatly improved; electroactive degradable polymer materials for nerve repair and cardiac scaffold materials and nanoparticle-enhanced aliphatic aggregation for bone repair are prepared. Ester composites, etc. (China Medical News)